Ontology highlight
ABSTRACT:
SUBMITTER: Teng Y
PROVIDER: S-EPMC3998093 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Teng Y Y Mei Y Y Hawthorn L L Cowell J K JK
Oncogene 20130114 2
The WASF3 gene promotes invasion and metastasis in breast cancer cells, which have undergone epithelial-to-mesenchyme transition (EMT). Overexpression of WASF3 in cells that do not show EMT increases their invasion potential as a result of increased ZEB1/2 levels, which specifically suppress the anti-invasion chromosome 1 miR-200a/200b/429 cluster. ZEB1/2 upregulation by WASF3 results from downregulation of KISS1, leading to the release of inhibition of nuclear factor (NF)κB by IκBα. We further ...[more]