Ontology highlight
ABSTRACT:
SUBMITTER: Vantourout P
PROVIDER: S-EPMC3998197 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Vantourout Pierre P Willcox Carrie C Turner Andrea A Swanson Chad M CM Haque Yasmin Y Sobolev Olga O Grigoriadis Anita A Tutt Andrew A Hayday Adrian A
Science translational medicine 20140401 231
Human cytolytic T lymphocytes and natural killer cells can limit tumor growth and are being increasingly harnessed for tumor immunotherapy. One way cytolytic lymphocytes recognize tumor cells is by engagement of their activating receptor, NKG2D, by stress antigens of the MICA/B and ULBP families. This study shows that surface up-regulation of NKG2D ligands by human epithelial cells in response to ultraviolet irradiation, osmotic shock, oxidative stress, and growth factor provision is attributabl ...[more]