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Mitochondrial DNA variation in human metabolic rate and energy expenditure.

ABSTRACT: The role of climate in driving selection of mtDNA as Homo sapiens migrated out of Africa into Eurasia remains controversial. We evaluated the role of mtDNA variation in resting metabolic rate (RMR) and total energy expenditure (TEE) among 294 older, community-dwelling African and European American adults from the Health, Aging and Body Composition Study. Common African haplogroups L0, L2 and L3 had significantly lower RMRs than European haplogroups H, JT and UK with haplogroup L1 RMR being intermediate to these groups. This study links mitochondrial haplogroups with ancestry-associated differences in metabolic rate and energy expenditure.

SUBMITTER: Tranah GJ

PROVIDER: S-EPMC3998521 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Mitochondrial DNA variation in human metabolic rate and energy expenditure.

Tranah Gregory J GJ Manini Todd M TM Lohman Kurt K KK Nalls Michael A MA Kritchevsky Stephen S Newman Anne B AB Harris Tamara B TB Miljkovic Iva I Biffi Alessandro A Cummings Steven R SR Liu Yongmei Y

Mitochondrion 20110509 6

The role of climate in driving selection of mtDNA as Homo sapiens migrated out of Africa into Eurasia remains controversial. We evaluated the role of mtDNA variation in resting metabolic rate (RMR) and total energy expenditure (TEE) among 294 older, community-dwelling African and European American adults from the Health, Aging and Body Composition Study. Common African haplogroups L0, L2 and L3 had significantly lower RMRs than European haplogroups H, JT and UK with haplogroup L1 RMR being inter ...[more]

PMID: 21586348

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