Contribution of network connectivity in determining the relationship between gene expression and metabolite concentration changes.

ABSTRACT: One of the primary mechanisms through which a cell exerts control over its metabolic state is by modulating expression levels of its enzyme-coding genes. However, the changes at the level of enzyme expression allow only indirect control over metabolite levels, for two main reasons. First, at the level of individual reactions, metabolite levels are non-linearly dependent on enzyme abundances as per the reaction kinetics mechanisms. Secondly, specific metabolite pools are tightly interlinked with the rest of the metabolic network through their production and consumption reactions. While the role of reaction kinetics in metabolite concentration control is well studied at the level of individual reactions, the contribution of network connectivity has remained relatively unclear. Here we report

SUBMITTER: Zelezniak A 

PROVIDER: S-EPMC3998873 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature