Ontology highlight
ABSTRACT:
SUBMITTER: Ebert S
PROVIDER: S-EPMC3999167 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Ebert Stefan S Becker Marc M Lemmermann Niels A W NA Büttner Julia K JK Michel Anastasija A Taube Christian C Podlech Jürgen J Böhm Verena V Freitag Kirsten K Thomas Doris D Holtappels Rafaela R Reddehase Matthias J MJ Stassen Michael M
PLoS pathogens 20140424 4
The lungs are a noted predilection site of acute, latent, and reactivated cytomegalovirus (CMV) infections. Interstitial pneumonia is the most dreaded manifestation of CMV disease in the immunocompromised host, whereas in the immunocompetent host lung-infiltrating CD8 T cells confine the infection in nodular inflammatory foci and prevent viral pathology. By using murine CMV infection as a model, we provide evidence for a critical role of mast cells (MC) in the recruitment of protective CD8 T cel ...[more]