Unknown

Dataset Information

0

Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study.


ABSTRACT: OBJECTIVE:To investigate the relationship between plasma levels of small dense low-density lipoprotein-cholesterol (sdLDL-C) and risk for incident coronary heart disease (CHD) in a prospective study among Atherosclerosis Risk in Communities (ARIC) study participants. APPROACH AND RESULTS:Plasma sdLDL-C was measured in 11 419 men and women of the biracial ARIC study using a newly developed homogeneous assay. A proportional hazards model was used to examine the relationship among sdLDL-C, vascular risk factors, and risk for CHD events (n=1158) for a period of ?11 years. Plasma sdLDL-C levels were strongly correlated with an atherogenic lipid profile and were higher in patients with diabetes mellitus than non-diabetes mellitus (49.6 versus 42.3 mg/dL; P<0.0001). In a model that included established risk factors, sdLDL-C was associated with incident CHD with a hazard ratio of 1.51 (95% confidence interval, 1.21-1.88) for the highest versus the lowest quartile, respectively. Even in individuals considered to be at low cardiovascular risk based on their LDL-C levels, sdLDL-C predicted risk for incident CHD (hazard ratio, 1.61; 95% confidence interval, 1.04-2.49). Genome-wide association analyses identified genetic variants in 8 loci associated with sdLDL-C levels. These loci were in or close to genes previously associated with risk for CHD. We discovered 1 novel locus, PCSK7, for which genetic variation was significantly associated with sdLDL-C and other lipid factors. CONCLUSIONS:sdLDL-C was associated with incident CHD in ARIC study participants. The novel association of genetic variants in PCSK7 with sdLDL-C and other lipid traits may provide new insights into the role of this gene in lipid metabolism.

SUBMITTER: Hoogeveen RC 

PROVIDER: S-EPMC3999643 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study.

Hoogeveen Ron C RC   Gaubatz John W JW   Sun Wensheng W   Dodge Rhiannon C RC   Crosby Jacy R JR   Jiang Jennifer J   Couper David D   Virani Salim S SS   Kathiresan Sekar S   Boerwinkle Eric E   Ballantyne Christie M CM  

Arteriosclerosis, thrombosis, and vascular biology 20140220 5


<h4>Objective</h4>To investigate the relationship between plasma levels of small dense low-density lipoprotein-cholesterol (sdLDL-C) and risk for incident coronary heart disease (CHD) in a prospective study among Atherosclerosis Risk in Communities (ARIC) study participants.<h4>Approach and results</h4>Plasma sdLDL-C was measured in 11 419 men and women of the biracial ARIC study using a newly developed homogeneous assay. A proportional hazards model was used to examine the relationship among sd  ...[more]

Similar Datasets

| PRJNA75713 | ENA
| S-EPMC3411890 | biostudies-literature
| S-EPMC4211254 | biostudies-literature
| S-EPMC3030449 | biostudies-literature
| S-EPMC5376064 | biostudies-literature
| S-EPMC5395073 | biostudies-literature
| phs000090.v1.p1 | EGA
| S-EPMC9576675 | biostudies-literature
| S-EPMC3893700 | biostudies-other
| S-EPMC6153245 | biostudies-other