Unknown

Dataset Information

0

A genome-wide regulatory network identifies key transcription factors for memory CD8? T-cell development.


ABSTRACT: Memory CD8? T-cell development is defined by the expression of a specific set of memory signature genes. Despite recent progress, many components of the transcriptional control of memory CD8? T-cell development are still unknown. To identify transcription factors and their interactions in memory CD8? T-cell development, we construct a genome-wide regulatory network and apply it to identify key transcription factors that regulate memory signature genes. Most of the known transcription factors having a role in memory CD8? T-cell development are rediscovered and about a dozen new ones are also identified. Sox4, Bhlhe40, Bach2 and Runx2 are experimentally verified, and Bach2 is further shown to promote both development and recall proliferation of memory CD8? T cells through Prdm1 and Id3. Gene perturbation study identifies the interactions between the transcription factors, with Sox4 positioned as a hub. The identified transcription factors and insights into their interactions should facilitate further dissection of molecular mechanisms underlying memory CD8? T-cell development.

SUBMITTER: Hu G 

PROVIDER: S-EPMC3999894 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

altmetric image

Publications

A genome-wide regulatory network identifies key transcription factors for memory CD8⁺ T-cell development.

Hu Guangan G   Chen Jianzhu J  

Nature communications 20130101


Memory CD8⁺ T-cell development is defined by the expression of a specific set of memory signature genes. Despite recent progress, many components of the transcriptional control of memory CD8⁺ T-cell development are still unknown. To identify transcription factors and their interactions in memory CD8⁺ T-cell development, we construct a genome-wide regulatory network and apply it to identify key transcription factors that regulate memory signature genes. Most of the known transcription factors hav  ...[more]

Similar Datasets

| S-EPMC5841439 | biostudies-literature
| S-EPMC8472308 | biostudies-literature
| S-EPMC2775518 | biostudies-literature
| S-EPMC8872562 | biostudies-literature
| S-EPMC7311676 | biostudies-literature
| S-EPMC5748172 | biostudies-literature
| S-EPMC8256865 | biostudies-literature
| S-EPMC6442555 | biostudies-literature
| S-EPMC8693779 | biostudies-literature
| S-EPMC3044298 | biostudies-literature