Ontology highlight
ABSTRACT:
SUBMITTER: Hu G
PROVIDER: S-EPMC3999894 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nature communications 20130101
Memory CD8⁺ T-cell development is defined by the expression of a specific set of memory signature genes. Despite recent progress, many components of the transcriptional control of memory CD8⁺ T-cell development are still unknown. To identify transcription factors and their interactions in memory CD8⁺ T-cell development, we construct a genome-wide regulatory network and apply it to identify key transcription factors that regulate memory signature genes. Most of the known transcription factors hav ...[more]