Dataset Information

Laminar and temporal expression dynamics of coding and noncoding RNAs in the mouse neocortex.

ABSTRACT: The hallmark of the cerebral neocortex is its organization into six layers, each containing a characteristic set of cell types and synaptic connections. The transcriptional events involved in laminar development and function still remain elusive. Here, we employed deep sequencing of mRNA and small RNA species to gain insights into transcriptional differences among layers and their temporal dynamics during postnatal development of the mouse primary somatosensory neocortex. We identify a number of coding and noncoding transcripts with specific spatiotemporal expression and splicing patterns. We also identify signature trajectories and gene coexpression networks associated with distinct biological processes and transcriptional overlap between these processes. Finally, we provide data that allow the study of potential miRNA and mRNA interactions. Overall, this study provides an integrated view of the laminar and temporal expression dynamics of coding and noncoding transcripts in the mouse neocortex and a resource for studies of neurodevelopment and transcriptome.

SUBMITTER: Fertuzinhos S

PROVIDER: S-EPMC3999901 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Laminar and temporal expression dynamics of coding and noncoding RNAs in the mouse neocortex.

Fertuzinhos Sofia S Li Mingfeng M Kawasawa Yuka Imamura YI Ivic Vedrana V Franjic Daniel D Singh Darshani D Crair Michael M Sestan Nenad N

Cell reports 20140220 5

The hallmark of the cerebral neocortex is its organization into six layers, each containing a characteristic set of cell types and synaptic connections. The transcriptional events involved in laminar development and function still remain elusive. Here, we employed deep sequencing of mRNA and small RNA species to gain insights into transcriptional differences among layers and their temporal dynamics during postnatal development of the mouse primary somatosensory neocortex. We identify a number of ...[more]

PMID: 24561256

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Dataset Information

Laminar and temporal expression dynamics of coding and noncoding RNAs in the mouse neocortex.

Publications

Laminar and temporal expression dynamics of coding and noncoding RNAs in the mouse neocortex.

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