Dataset Information

Cross-sectional study of the relationship of peripheral blood cell profiles with severity of infection by adenovirus type 55.

ABSTRACT:

Background

The immunologic profiles of patients with human adenovirus serotype 55 (HAdV-55) infections were characterized in subjects diagnosed with silent infections (n?=?30), minor infections (n?=?27), severe infections (n?=?34), and healthy controls (n?=?30) during a recent outbreak among Chinese military trainees.

Methods

Blood was sampled at the disease peak and four weeks later, and samples were analyzed to measure changes in leukocyte and platelet profiles in patients with different severities of disease. Differential lymphocyte subsets and cytokine profiles were measured by flow cytometry and Luminex xMAP®, and serum antibodies were analyzed by ELISA and immunofluorescence staining.

Results

Patients with severe HAdV infections had higher proportions of neutrophils and reduced levels of lymphocytes (p?ConclusionsPatients with different severities of disease due to HAdV-55 infection had significantly different immune responses. These data provide an initial step toward the identification of patients at risk for more severe disease and the development of treatments against HAdV-55 infection.

SUBMITTER: Chen WW

PROVIDER: S-EPMC4000060 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Publications

Cross-sectional study of the relationship of peripheral blood cell profiles with severity of infection by adenovirus type 55.

Chen Wei-Wei WW Nie Wei-Min WM Xu Wen W Xie Yang-Xin YX Tu Bo B Zhao Peng P Qin En-Qiang EQ Zhang Yun-Hui YH Zhang Xiu X Li Wen-Gang WG Zhou Zhi-Ping ZP Lv Ji-Yun JY Zhao Min M

BMC infectious diseases 20140319

<h4>Background</h4>The immunologic profiles of patients with human adenovirus serotype 55 (HAdV-55) infections were characterized in subjects diagnosed with silent infections (n = 30), minor infections (n = 27), severe infections (n = 34), and healthy controls (n = 30) during a recent outbreak among Chinese military trainees.<h4>Methods</h4>Blood was sampled at the disease peak and four weeks later, and samples were analyzed to measure changes in leukocyte and platelet profiles in patients with ...[more]

PMID: 24646014

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Project description:BackgroundWhether an association between alcohol consumption and dental caries exists is still unclear. Chinese Baijiu is the most common alcohol consumed by middle-aged and elderly Chinese individuals. This study aimed to assess the relationship between alcohol consumption (Chinese Baijiu) and dental caries in Guangdong Province, southern China.MethodsA cross-sectional study was conducted in Guangdong Province using a multistage, stratified, equal-sized, random sampling strategy. In total, 576 individuals aged 55-74 were recruited to fill out a questionnaire through face-to-face and one-on-one interviews and to undergo a series of dental examinations with a Community Periodontal Index (CPI) probe. According to the standard for clinical dentition examination of the WHO 2013 criteria, the presence of dental caries was determined by the DFT/DFRoot (decayed-filled tooth/root) index. The ratios of males to females and urban people to countrymen were both 1:1. Then, the chi-square test and rank-sum tests were used to compare the differences in caries between subgroups, and multivariate logistic regression analyses, as well as negative binomial regression analyses, were executed to identify the potential relationship between alcohol consumption and caries.ResultsThe prevalence of crown caries was 79.17% with a DFT index of 3.19, while that of root caries was 61.28% with a DFRoot index of 2.08. The prevalence and mean tooth of crown caries of females were higher than those of males. The prevalence and mean DFRoot of root caries in rural areas were higher than those in urban areas. The results of the multivariate logistic regression analysis and negative binomial regression analysis showed that there was a statistically significant negative correlation between the consumption frequency of Chinese Baijiu and caries (often vs. never/rarely, crown caries: odds ratio (OR) = 0.54, 95% confidence interval (CI): 0.26-1.13, P = 0.103, incidence rate ratio (IRR) = 0.63, 95% CI: 0.44-0.92, P = 0.015; root caries: OR = 0.47, 95% CI: 0.24-0.93, P = 0.030, IRR = 0.52, 95% CI: 0.32-0.54, P = 0.008).ConclusionsWithin the limitations of this study, frequent consumption of Chinese Baijiu was a protective factor for caries in middle-aged and elderly people in Guangdong Province. However, considering the harm of alcohol to one's general health, it is recommended to drink moderately and avoid alcohol abuse.

Dataset Information

Cross-sectional study of the relationship of peripheral blood cell profiles with severity of infection by adenovirus type 55.

Background

Methods

Results

Publications

Cross-sectional study of the relationship of peripheral blood cell profiles with severity of infection by adenovirus type 55.

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