Ontology highlight
ABSTRACT:
SUBMITTER: Behrends M
PROVIDER: S-EPMC4000169 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Behrends Malte M Wallinder Charlotta C Wieckowska Anna A Guimond Marie-Odile MO Hallberg Anders A Gallo-Payet Nicole N Larhed Mats M
ChemistryOpen 20140313 2
A novel series of ligands for the recombinant human AT2 receptor has been synthesized utilizing a fast and efficient palladium-catalyzed procedure for aminocarbonylation as the key reaction. Molybdenum hexacarbonyl [Mo(CO)6] was employed as the carbon monoxide source, and controlled microwave heating was applied. The prepared N-aryl isoleucine derivatives, encompassing a variety of amide groups attached to the aromatic system, exhibit binding affinities at best with K i values in the low micromo ...[more]