Ontology highlight
ABSTRACT:
SUBMITTER: Kurachi M
PROVIDER: S-EPMC4000237 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Kurachi Makoto M Barnitz R Anthony RA Yosef Nir N Odorizzi Pamela M PM DiIorio Michael A MA Lemieux Madeleine E ME Yates Kathleen K Godec Jernej J Klatt Martin G MG Regev Aviv A Wherry E John EJ Haining W Nicholas WN
Nature immunology 20140302 4
The transcription factor BATF is required for the differentiation of interleukin 17 (IL-17)-producing helper T cells (TH17 cells) and follicular helper T cells (TFH cells). Here we identified a fundamental role for BATF in regulating the differentiation of effector of CD8(+) T cells. BATF-deficient CD8(+) T cells showed profound defects in effector population expansion and underwent proliferative and metabolic catastrophe early after encountering antigen. BATF, together with the transcription fa ...[more]