Ontology highlight
ABSTRACT:
SUBMITTER: Lin AC
PROVIDER: S-EPMC4000970 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Lin Andrew C AC Bygrave Alexei M AM de Calignon Alix A Lee Tzumin T Miesenböck Gero G
Nature neuroscience 20140223 4
Sparse coding may be a general strategy of neural systems for augmenting memory capacity. In Drosophila melanogaster, sparse odor coding by the Kenyon cells of the mushroom body is thought to generate a large number of precisely addressable locations for the storage of odor-specific memories. However, it remains untested how sparse coding relates to behavioral performance. Here we demonstrate that sparseness is controlled by a negative feedback circuit between Kenyon cells and the GABAergic ante ...[more]