Ontology highlight
ABSTRACT:
SUBMITTER: Kepler TB
PROVIDER: S-EPMC4001017 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Kepler Thomas B TB Munshaw Supriya S Wiehe Kevin K Zhang Ruijun R Yu Jae-Sung JS Woods Christopher W CW Denny Thomas N TN Tomaras Georgia D GD Alam S Munir SM Moody M Anthony MA Kelsoe Garnett G Liao Hua-Xin HX Haynes Barton F BF
Frontiers in immunology 20140422
Affinity maturation of the antibody response is a fundamental process in adaptive immunity during which B-cells activated by infection or vaccination undergo rapid proliferation accompanied by the acquisition of point mutations in their rearranged immunoglobulin (Ig) genes and selection for increased affinity for the eliciting antigen. The rate of somatic hypermutation at any position within an Ig gene is known to depend strongly on the local DNA sequence, and Ig genes have region-specific codon ...[more]