Dataset Information

Faster cognitive decline in elders without dementia and decreased risk of cancer mortality: NEDICES Study.

ABSTRACT:

Objective

To assess whether faster cognitive decline in elders without dementia is associated with decreased risk of cancer mortality.

Methods

In this population-based, prospective study of 2,627 people without dementia aged 65 years and older (Neurological Disorders in Central Spain), a 37-item version of the Mini-Mental State Examination (37-MMSE) was administered at 2 visits (baseline and follow-up, approximately 3 years later). We divided change in 37-MMSE into tertiles (lower tertile ? 2 point improvement in score, higher tertile ? 2 point decline in score). Community-dwelling elders were followed for a median of 12.9 years, after which the death certificates of those who died were examined.

Results

A total of 1,003 (38.2%) died, including 339 (33.8%) deaths among participants who were in the higher tertile of 37-MMSE change and 664 (66.2%) deaths among those in the remaining tertiles. Cancer was reported significantly less often in those in the higher tertile of MMSE change (20.6%) than in those in the remaining tertiles (28.6%): in an unadjusted Cox model, hazard ratio for cancer mortality in participants within the higher tertile = 0.75 (p = 0.04) compared with the participants within the remaining tertiles. In a Cox model that adjusted for a variety of demographic factors and comorbidities, hazard ratio for cancer mortality in participants within the higher tertile = 0.70 (p = 0.01).

Conclusion

In this population-based, prospective study of community-dwelling elders without dementia, faster cognitive decline was associated with a decreased risk of cancer mortality. Further studies are required to elucidate this inverse association in elders without dementia.

SUBMITTER: Benito-Leon J

PROVIDER: S-EPMC4001199 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Publications

Faster cognitive decline in elders without dementia and decreased risk of cancer mortality: NEDICES Study.

Benito-León Julián J Romero Juan Pablo JP Louis Elan D ED Bermejo-Pareja Félix F

Neurology 20140409 16

<h4>Objective</h4>To assess whether faster cognitive decline in elders without dementia is associated with decreased risk of cancer mortality.<h4>Methods</h4>In this population-based, prospective study of 2,627 people without dementia aged 65 years and older (Neurological Disorders in Central Spain), a 37-item version of the Mini-Mental State Examination (37-MMSE) was administered at 2 visits (baseline and follow-up, approximately 3 years later). We divided change in 37-MMSE into tertiles (lower ...[more]

PMID: 24719490

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Dataset Information

Faster cognitive decline in elders without dementia and decreased risk of cancer mortality: NEDICES Study.

Objective

Methods

Results

Conclusion

Publications

Faster cognitive decline in elders without dementia and decreased risk of cancer mortality: NEDICES Study.

Similar Datasets

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