Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto-Tanaka M
PROVIDER: S-EPMC4001300 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Yamamoto-Tanaka M M Makino T T Motoyama A A Miyai M M Tsuboi R R Hibino T T
Cell death & disease 20140417
Loss of the nucleus is a critical step in keratinocyte terminal differentiation. To elucidate the mechanisms involved, we focused on two characteristic events: nuclear translocation of N-terminal fragment of profilaggrin and caspase-14-dependent degradation of the inhibitor of caspase-activated DNase (ICAD). First, we demonstrated that epidermal mesotrypsin liberated a 55-kDa N-terminal fragment of profilaggrin (FLG-N) and FLG-N was translocated into the nucleus. Interestingly, these cells becam ...[more]