Ontology highlight
ABSTRACT:
SUBMITTER: Liu Q
PROVIDER: S-EPMC4001531 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Liu Qiuzhen Q Tomei Sara S Ascierto Maria Libera ML De Giorgi Valeria V Bedognetti Davide D Dai Cuilian C Uccellini Lorenzo L Spivey Tara T Pos Zoltan Z Thomas Jaime J Reinboth Jennifer J Murtas Daniela D Zhang Qianbing Q Chouchane Lotfi L Weiss Geoffrey R GR Slingluff Craig L CL Lee Peter P PP Rosenberg Steven A SA Alter Harvey H Yao Kaitai K Wang Ena E Marincola Francesco M FM
The Journal of clinical investigation 20140401 5
In multiple forms of cancer, constitutive activation of type I IFN signaling is a critical consequence of immune surveillance against cancer; however, PBMCs isolated from cancer patients exhibit depressed STAT1 phosphorylation in response to IFN-α, suggesting IFN signaling dysfunction. Here, we demonstrated in a coculture system that melanoma cells differentially impairs the IFN-α response in PBMCs and that the inhibitory potential of a particular melanoma cell correlates with NOS1 expression. C ...[more]