Ontology highlight
ABSTRACT:
SUBMITTER: Zohar Y
PROVIDER: S-EPMC4001543 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Zohar Yaniv Y Wildbaum Gizi G Novak Rostislav R Salzman Andrew L AL Thelen Marcus M Alon Ronen R Barsheshet Yiftah Y Karp Christopher L CL Karin Nathan N
The Journal of clinical investigation 20140408 5
A single G protein-coupled receptor (GPCR) can activate multiple signaling cascades based on the binding of different ligands. The biological relevance of this feature in immune regulation has not been evaluated. The chemokine-binding GPCR CXCR3 is preferentially expressed on CD4+ T cells, and canonically binds 3 structurally related chemokines: CXCL9, CXCL10, and CXCL11. Here we have shown that CXCL10/CXCR3 interactions drive effector Th1 polarization via STAT1, STAT4, and STAT5 phosphorylation ...[more]