Ontology highlight
ABSTRACT:
SUBMITTER: Yerges-Armstrong LM
PROVIDER: S-EPMC4001726 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Yerges-Armstrong L M LM Ellero-Simatos S S Georgiades A A Zhu H H Lewis J P JP Horenstein R B RB Beitelshees A L AL Dane A A Reijmers T T Hankemeier T T Fiehn O O Shuldiner A R AR Kaddurah-Daouk R R
Clinical pharmacology and therapeutics 20130611 4
Although aspirin is a well-established antiplatelet agent, the mechanisms of aspirin resistance remain poorly understood. Metabolomics allows for measurement of hundreds of small molecules in biological samples, enabling detailed mapping of pathways involved in drug response. We defined the metabolic signature of aspirin exposure in subjects from the Heredity and Phenotype Intervention Heart Study. Many metabolites, including known aspirin catabolites, changed on exposure to aspirin, and pathway ...[more]