Ontology highlight
ABSTRACT:
SUBMITTER: Phillips CM
PROVIDER: S-EPMC4001799 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Phillips Carolyn M CM Meng Xiangdong X Zhang Lei L Chretien Jacqueline H JH Urnov Fyodor D FD Dernburg Abby F AF
Nature cell biology 20090720 8
Caenorhabditis elegans chromosomes contain specialized regions called pairing centres, which mediate homologous pairing and synapsis during meiosis. Four related proteins, ZIM-1, 2, 3 and HIM-8, associate with these sites and are required for their essential functions. Here we show that short sequence elements enriched in the corresponding chromosome regions selectively recruit these proteins in vivo. In vitro analysis using SELEX indicates that the binding specificity of each protein arises fro ...[more]