Ontology highlight
ABSTRACT:
SUBMITTER: Tani H
PROVIDER: S-EPMC4001919 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Tani Hiroaki H Dulla Chris G CG Farzampour Zoya Z Taylor-Weiner Amaro A Huguenard John R JR Reimer Richard J RJ
Neuron 20140201 4
Biochemical studies suggest that excitatory neurons are metabolically coupled with astrocytes to generate glutamate for release. However, the extent to which glutamatergic neurotransmission depends on this process remains controversial because direct electrophysiological evidence is lacking. The distance between cell bodies and axon terminals predicts that glutamine-glutamate cycle is synaptically localized. Hence, we investigated isolated nerve terminals in brain slices by transecting hippocamp ...[more]