Ontology highlight
ABSTRACT:
SUBMITTER: Pemmaraju B
PROVIDER: S-EPMC4001930 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Tetrahedron letters 20140301 12
A number of 5'-<i>O</i>-dicarboxylic fatty acyl monoester derivatives of 3'-azido-3'-deoxythymidine (zidovudine, AZT), 2',3'-didehydro-2',3'-dideoxythymidine (stavudine, d4T), and 3'-fluoro-3'-deoxythymidine (alovudine, FLT) were synthesized to improve the lipophilicity and potentially the cellular delivery of parent polar 2', 3'-dideoxynucleoside (ddN) analogues. The compounds were evaluated for their anti-HIV activity. Three different fatty acids with varying chain length of suberic acid (octa ...[more]