Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics.
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ABSTRACT:
SUBMITTER: He JX
PROVIDER: S-EPMC4002295 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
Poly(ADP-ribose) polymerase inhibitors as promising cancer therapeutics.
He Jin-xue JX Yang Chun-hao CH Miao Ze-hong ZH
Acta pharmacologica Sinica 20100802 9
The year of 2005 was a watershed in the history of poly(ADP-ribose) polymerase (PARP) inhibitors due to the important findings of selective killing in BRCA-deficient cancers by PARP inhibition. The findings made PARP inhibition one of the most promising new therapeutic approaches to cancers, especially to those with specific defects. With AZD2281 and BSI-201 entering phase III clinical trials, the final application of PARP inhibitors in clinic would come true soon. This current paper will review ...[more]
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