Ontology highlight
ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC4003182 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Zhang Chunyan C Bai Nan N Chang Antao A Zhang Zhuhong Z Yin Jing J Shen Wenzhi W Tian Yaping Y Xiang Rong R Liu Chenghu C
Cellular & molecular immunology 20121217 1
Toll-like receptors (TLRs) are sentinels of the host defense system, which recognize a large number of microbial pathogens. The host defense system may be inefficient or inflammatory diseases may develop if microbial recognition by TLRs and subsequent TLR-triggered cytokine production are deregulated. Activating transcription factor 4 (ATF4), a member of the ATF/CREB transcription factor family, is an important factor that participates in several pathophysiological processes. In this report, we ...[more]