Ontology highlight
ABSTRACT:
SUBMITTER: Heitzer E
PROVIDER: S-EPMC4003352 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Current opinion in genetics & development 20140226
Three DNA polymerases - Pol α, Pol δ and Pol ɛ - are essential for DNA replication. After initiation of DNA synthesis by Pol α, Pol δ or Pol ɛ take over on the lagging and leading strand respectively. Pol δ and Pol ɛ perform the bulk of replication with very high fidelity, which is ensured by Watson-Crick base pairing and 3'exonuclease (proofreading) activity. Yeast models have shown that mutations in the exonuclease domain of Pol δ and Pol ɛ homologues can cause a mutator phenotype. Recently, w ...[more]