ADAM metallopeptidase domain 33 (ADAM33): a promising target for asthma.

ABSTRACT: Over the last few years, a significant progress has been made in understanding the role of a disintegrin and metalloproteinase 33 (ADAM33) in asthma. The previous observations for the association with asthma have been replicated in over 33 different population samples worldwide. We and others have performed association analysis and meta-analysis and provided further evidence that several polymorphisms in the ADAM33 are risk factors for asthma, especially in the Asian population. Further, several studies have suggested that alterations in epigenetic marks alter the patterns of DNA methylation of ADAM33 and result in potentially adverse biological effects. Finally, while the biological activities of ADAM33 are as yet unknown, ADAM33 may play a possible role in airway remodeling because of it

SUBMITTER: Tripathi P 

PROVIDER: S-EPMC4003756 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature