Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy.
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ABSTRACT:
SUBMITTER: Katagi M
PROVIDER: S-EPMC4004028 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy.
Katagi Miwako M Terashima Tomoya T Okano Junko J Urabe Hiroshi H Nakae Yuki Y Ogawa Nobuhiro N Udagawa Jun J Maegawa Hiroshi H Matsumura Kazuhiro K Chan Lawrence L Kojima Hideto H
FEBS letters 20140225 6
Diabetic peripheral neuropathy is a major chronic diabetic complication. We have previously shown that in type 1 diabetic streptozotocin-treated mice, insulin- and TNF-α co-expressing bone marrow-derived cells (BMDCs) induced by hyperglycemia travel to nerve tissues where they fuse with nerve cells, causing premature apoptosis and nerve dysfunction. Here we show that similar BMDCs also occur in type 2 diabetic high-fat diet (HFD) mice. Furthermore, we found that hyperglycemia induces the co-expr ...[more]
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