Targeted deletion of RasGRP1 impairs skin tumorigenesis.
Ontology highlight
ABSTRACT:
SUBMITTER: Sharma A
PROVIDER: S-EPMC4004207 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Targeted deletion of RasGRP1 impairs skin tumorigenesis.
Sharma Amrish A Fonseca Lauren L LL Rajani Cynthia C Yanagida Jodi K JK Endo Yuka Y Cline J Mark JM Stone James C JC Ji Junfang J Ramos Joe W JW Lorenzo Patricia S PS
Carcinogenesis 20140124 5
Ras is frequently activated in cutaneous squamous cell carcinoma, a prevalent form of skin cancer. However, the pathways that contribute to Ras-induced transformation have not been entirely elucidated. We have previously demonstrated that in transgenic mice, overexpression of the Ras activator RasGRP1 promotes the formation of spontaneous skin tumors and enhances malignant progression in the multistage carcinogenesis skin model that relies on the oncogenic activation of H-Ras. Utilizing a RasGRP ...[more]
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