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X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from A?(17-36).

ABSTRACT: A peptide derived from A?17-36 crystallizes to form trimers that further associate to form higher-order oligomers. The trimers consist of three highly twisted ?-hairpins in a triangular arrangement. Two trimers associate face-to-face in the crystal lattice to form a hexamer; four trimers in a tetrahedral arrangement about a central cavity form a dodecamer. These structures provide a working model for the structures of oligomers associated with neurodegeneration in Alzheimer's disease.

SUBMITTER: Spencer RK

PROVIDER: S-EPMC4004244 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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X-ray crystallographic structures of trimers and higher-order oligomeric assemblies of a peptide derived from Aβ(17-36).

Spencer Ryan K RK Li Hao H Nowick James S JS

Journal of the American Chemical Society 20140403 15

A peptide derived from Aβ17-36 crystallizes to form trimers that further associate to form higher-order oligomers. The trimers consist of three highly twisted β-hairpins in a triangular arrangement. Two trimers associate face-to-face in the crystal lattice to form a hexamer; four trimers in a tetrahedral arrangement about a central cavity form a dodecamer. These structures provide a working model for the structures of oligomers associated with neurodegeneration in Alzheimer's disease. ...[more]

PMID: 24669800

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