Secretion of interleukin-17 by CD8+ T cells expressing CD146 (MCAM).
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ABSTRACT:
SUBMITTER: Dagur PK
PROVIDER: S-EPMC4004661 | biostudies-literature | 2014 May-Jun
REPOSITORIES: biostudies-literature
Publications
Secretion of interleukin-17 by CD8+ T cells expressing CD146 (MCAM).
Dagur Pradeep K PK Biancotto Angélique A Stansky Elena E Sen H Nida HN Nussenblatt Robert B RB McCoy J Philip JP
Clinical immunology (Orlando, Fla.) 20140213 1-2
Interleukin-17 (IL-17) has been associated with the pathogenesis of numerous autoimmune diseases. CD4+ T cells secreting IL-17 are termed Th17 cells. CD8+ T cells, designated Tc17 cells, are also capable of secreting IL-17. Here we describe a population of Tc17 cells characterized by the expression of surface CD146, an endothelial adhesion molecule. These cells display signatures of a human Tc17 genotype and phenotype. Circulating CD8+CD146+ T cells are present in low levels in healthy adults. E ...[more]
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