Ontology highlight
ABSTRACT:
SUBMITTER: Suva ML
PROVIDER: S-EPMC4004670 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Suvà Mario L ML Rheinbay Esther E Gillespie Shawn M SM Patel Anoop P AP Wakimoto Hiroaki H Rabkin Samuel D SD Riggi Nicolo N Chi Andrew S AS Cahill Daniel P DP Nahed Brian V BV Curry William T WT Martuza Robert L RL Rivera Miguel N MN Rossetti Nikki N Kasif Simon S Beik Samantha S Kadri Sabah S Tirosh Itay I Wortman Ivo I Shalek Alex K AK Rozenblatt-Rosen Orit O Regev Aviv A Louis David N DN Bernstein Bradley E BE
Cell 20140410 3
Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors may also depend on cellular hierarchies reminiscent of normal development but superimposed on underlying genetic aberrations. In glioblastoma (GBM), a subset of stem-like tumor-propagating cells (TPCs) appears to drive tumor progression and underlie therapeutic resistance yet remain poorly understood. Here, we iden ...[more]