Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer.
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ABSTRACT:
SUBMITTER: Shi J
PROVIDER: S-EPMC4004960 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer.
Shi Jian J Wang Yifan Y Zeng Lei L Wu Yadi Y Deng Jiong J Zhang Qiang Q Lin Yiwei Y Li Junlin J Kang Tiebang T Tao Min M Rusinova Elena E Zhang Guangtao G Wang Chi C Zhu Haining H Yao Jun J Zeng Yi-Xin YX Evers B Mark BM Zhou Ming-Ming MM Zhou Binhua P BP
Cancer cell 20140201 2
Twist is a key transcription activator of epithelial-mesenchymal transition (EMT). It remains unclear how Twist induces gene expression. Here we report a mechanism by which Twist recruits BRD4 to direct WNT5A expression in basal-like breast cancer (BLBC). Twist contains a "histone H4-mimic" GK-X-GK motif that is diacetylated by Tip60. The diacetylated Twist binds the second bromodomain of BRD4, whose first bromodomain interacts with acetylated H4, thereby constructing an activated Twist/BRD4/P-T ...[more]
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