Ontology highlight
ABSTRACT:
SUBMITTER: Tampe B
PROVIDER: S-EPMC4005308 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Journal of the American Society of Nephrology : JASN 20140130 5
Methylation of CpG island promoters is an epigenetic event that can effectively silence transcription over multiple cell generations. Hypermethylation of the Rasal1 promoter contributes to activation of fibroblasts and progression of kidney fibrosis. Here, we explored whether such causative hypermethylation could be reversed through endogenous mechanisms and whether such reversal of hypermethylation is a constituent of the antifibrotic activity of bone morphogenic protein 7 (BMP7). We show that ...[more]