Ontology highlight
ABSTRACT:
SUBMITTER: Tiruppathi C
PROVIDER: S-EPMC4005385 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Tiruppathi Chinnaswamy C Soni Dheeraj D Wang Dong-Mei DM Xue Jiaping J Singh Vandana V Thippegowda Prabhakar B PB Cheppudira Bopaiah P BP Mishra Rakesh K RK Debroy Auditi A Qian Zhijian Z Bachmaier Kurt K Zhao You-Yang YY Christman John W JW Vogel Stephen M SM Ma Averil A Malik Asrar B AB
Nature immunology 20140202 3
Here we found that the transcription repressor DREAM bound to the promoter of the gene encoding A20 to repress expression of this deubiquitinase that suppresses inflammatory NF-κB signaling. DREAM-deficient mice displayed persistent and unchecked A20 expression in response to endotoxin. DREAM functioned by transcriptionally repressing A20 through binding to downstream regulatory elements (DREs). In contrast, binding of the transcription factor USF1 to the DRE-associated E-box domain in the gene ...[more]