Explaining the correlations among properties of mammalian promoters.
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ABSTRACT:
SUBMITTER: Frith MC
PROVIDER: S-EPMC4005656 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Explaining the correlations among properties of mammalian promoters.
Nucleic acids research 20140327 8
Proximal promoters are fundamental genomic elements for gene expression. They vary in terms of GC percentage, CpG abundance, presence of TATA signal, evolutionary conservation, chromosomal spread of transcription start sites and breadth of expression across cell types. These properties are correlated, and it has been suggested that there are two classes of promoters: one class with high CpG, widely spread transcription start sites and broad expression, and another with TATA signals, narrow sprea ...[more]
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