Ontology highlight
ABSTRACT:
SUBMITTER: Sipova H
PROVIDER: S-EPMC4005664 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Šipova Hana H Špringer Tomaš T Rejman Dominik D Šimak Ondřej O Petrová Magdalena M Novák Pavel P Rosenbergová Šarka Š Páv Ondřej O Liboska Radek R Barvík Ivan I Štěpanek Josef J Rosenberg Ivan I Homola Jiři J
Nucleic acids research 20140212 8
Several oligothymidylates containing various ratios of phosphodiester and isopolar 5'-hydroxyphosphonate, 5'-O-methylphosphonate and 3'-O-methylphosphonate internucleotide linkages were examined with respect to their hybridization properties with oligoriboadenylates and their ability to induce RNA cleavage by ribonuclease H (RNase H). The results demonstrated that the increasing number of 5'-hydroxyphosphonate or 5'-O-methylphosphonate units in antisense oligonucleotides (AOs) significantly stab ...[more]