Ontology highlight
ABSTRACT:
SUBMITTER: Taylor MB
PROVIDER: S-EPMC4006734 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Taylor Matthew B MB Ehrenreich Ian M IM
PLoS genetics 20140501 5
Recent research suggests that genetic interactions involving more than two loci may influence a number of complex traits. How these 'higher-order' interactions arise at the genetic and molecular levels remains an open question. To provide insights into this problem, we dissected a colony morphology phenotype that segregates in a yeast cross and results from synthetic higher-order interactions. Using backcrossing and selective sequencing of progeny, we found five loci that collectively produce th ...[more]