Ontology highlight
ABSTRACT:
SUBMITTER: Davies EL
PROVIDER: S-EPMC4006830 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Davies Erin L EL Lim Jaclyn G Y JG Joo William J WJ Tam Cheuk Ho CH Fuller Margaret T MT
Developmental biology 20121115 2
Stem cell behavior is regulated by extrinsic signals from specialized microenvironments, or niches, and intrinsic factors required for execution of context-appropriate responses to niche signals. Here we show that function of the transcriptional regulator longitudinals lacking (lola) is required cell autonomously for germline stem cell and somatic cyst stem cell maintenance in the Drosophila testis. In addition, lola is also required for proper execution of key developmental transitions during m ...[more]