Ontology highlight
ABSTRACT:
SUBMITTER: Antoon JW
PROVIDER: S-EPMC4007162 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Antoon James W JW Meacham William D WD Bratton Melyssa R MR Slaughter Evelyn M EM Rhodes Lyndsay V LV Ashe Hasina B HB Wiese Thomas E TE Burow Matthew E ME Beckman Barbara S BS
Journal of molecular endocrinology 20110428 3
Recently, crosstalk between sphingolipid signaling pathways and steroid hormones has been illuminated as a possible therapeutic target. Sphingosine kinase (SK), the key enzyme metabolizing pro-apoptotic ceramide to pro-survival sphingosine-1-phosphate (S1P), is a promising therapeutic target for solid tumor cancers. In this study, we examined the ability of pharmacological inhibition of S1P formation to block estrogen signaling as a targeted breast cancer therapy. We found that the Sphk1/2 selec ...[more]