Ontology highlight
ABSTRACT:
SUBMITTER: Tan K
PROVIDER: S-EPMC4007423 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Tan Kemin K Chhor Gekleng G Binkowski T Andrew TA Jedrzejczak Robert P RP Makowska-Grzyska Magdalena M Joachimiak Andrzej A
The Journal of biological chemistry 20140226 18
The overproduction of polysaccharide alginate is responsible for the formation of mucus in the lungs of cystic fibrosis patients. Histidine kinase KinB of the KinB-AlgB two-component system in Pseudomonas aeruginosa acts as a negative regulator of alginate biosynthesis. The modular architecture of KinB is similar to other histidine kinases. However, its periplasmic signal sensor domain is unique and is found only in the Pseudomonas genus. Here, we present the first crystal structures of the KinB ...[more]