Ontology highlight
ABSTRACT:
SUBMITTER: Pan S
PROVIDER: S-EPMC4007689 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20100316 3
The blockade of aberrant hedgehog (Hh) signaling has shown promise for therapeutic intervention in cancer. A cell-based phenotypic high-throughput screen was performed, and the lead structure (1) was identified as an inhibitor of the Hh pathway via antagonism of the Smoothened receptor (Smo). Structure-activity relationship studies led to the discovery of a potent and specific Smoothened antagonist N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carbox ...[more]