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Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families.


ABSTRACT: AIM: To determine the associations between HOXD4 gene polymorphisms with peak bone mineral density (BMD) throughing measuring three tagging single nucleotide polymorphisms (tagSNPs), including rs1867863, rs13418078, and rs4972504, in HOXD4. METHODS: Four hundred Chinese nuclear families with male offspring (1215 subjects) and 401 Chinese nuclear families with female offspring (1260 subjects) were recruited. BMD of the lumbar spine 1-4 (L1-4) and left proximal femur including total hip and femoral neck were measured by dual-energy X-ray absorptiometry. The quantitative transmission disequilibrium test (QTDT) was performed to investigate the association among the tagging SNPs, haplotypes and peak BMD. RESULTS: Only the CC genotype was identified in rs13418078 in the Chinese population, unlike other populations. We failed to find significant within-family association among these SNPs, haplotypes and peak BMD at any bone site in either male- or female-offspring nuclear families. CONCLUSION: The results suggest that genetic polymorphisms in HOXD4 may not be a major contributor to the observed variability in peak BMD in the lumbar spine and the hip in Chinese men and women.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC4007810 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families.

Zhang Hao H   He Jin-wei JW   Gao Gao G   Yue Hua H   Yu Jin-bo JB   Hu Wei-wei WW   Gu Jie-mei JM   Hu Yun-qiu YQ   Li Miao M   Fu Wen-zhen WZ   Liu Yu-juan YJ   Zhang Zhen-lin ZL  

Acta pharmacologica Sinica 20100801 8


<h4>Aim</h4>To determine the associations between HOXD4 gene polymorphisms with peak bone mineral density (BMD) throughing measuring three tagging single nucleotide polymorphisms (tagSNPs), including rs1867863, rs13418078, and rs4972504, in HOXD4.<h4>Methods</h4>Four hundred Chinese nuclear families with male offspring (1215 subjects) and 401 Chinese nuclear families with female offspring (1260 subjects) were recruited. BMD of the lumbar spine 1-4 (L1-4) and left proximal femur including total h  ...[more]

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