Ontology highlight
ABSTRACT:
SUBMITTER: Yang ZQ
PROVIDER: S-EPMC4007914 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20100824 9
A novel phenyl acetamide series of short-acting T-type calcium channel antagonists has been identified and evaluated using in vitro and in vivo assays. Heterocycle substitutions of the 4-position of the phenyl acetamides afforded potent and selective antagonists that exhibited desired short plasma half-lives across preclinical species. Lead compound TTA-A8 emerged as a compound with excellent in vivo efficacy as indicated by its significant modulation of rat sleep architecture in an EEG telemetr ...[more]