Ontology highlight
ABSTRACT:
SUBMITTER: Zhou H
PROVIDER: S-EPMC4007969 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Zhou Huiqiang H Danger Dana P DP Dock Steven T ST Hawley Lora L Roller Shane G SG Smith Chari D CD Handlon Anthony L AL
ACS medicinal chemistry letters 20100129 1
A series of benzisothiazole- and indolizine-β-d-glucopyranoside inhibitors of human SGLT2 are described. The synthesis of the C-linked heterocyclic glucosides took advantage of a palladium-catalyzed cross-coupling reaction between a glucal boronate and the corresponding bromo heterocycle. The compounds have been evaluated for their human SGLT2 inhibition potential using cell-based functional transporter assays, and their structure-activity relationships have been described. Benzisothiazole-C-glu ...[more]