Dataset Information

25-hydroxyvitamin D and parathyroid hormone levels do not predict changes in carotid arterial stiffness: the Multi-Ethnic Study of Atherosclerosis.

ABSTRACT: OBJECTIVE:To evaluate the impact of vitamin D and parathyroid hormone (PTH) on longitudinal changes in arterial stiffness. APPROACH AND RESULTS:Distensibility coefficient and Young's elastic modulus of the right common carotid artery were evaluated at baseline and after a mean (SD) of 9.4 (0.5) years in 2580 Multi-Ethnic Study of Atherosclerosis (MESA) participants. Cross-sectional and longitudinal associations were evaluated using multivariable linear regression and analysis of covariance. At baseline, participants were 60.1 (9.4) years old (54% female; 26% black, 20% Hispanic, 14% Chinese). Mean annualized 25(OH)D was <20 ng/dL in 816 participants, and PTH was >65 pg/dL in 285 participants. In cross-sectional analyses, low 25(OH)D (<20 ng/mL) was not associated with stiffer arteries after adjustment for cardiovascular disease risk factors (P>0.4). PTH >65 pg/mL was associated with stiffer arteries after adjustment for cardiovascular disease risk factors, other than systolic blood pressure (distensibility coefficient: ?=-2.4×10(-4) mm Hg(-1), P=0.003; Young's elastic modulus: ?=166 mm Hg, P=0.01); however, after adjustment for systolic blood pressure, these associations no longer were statistically significant. Longitudinal arterial stiffening was associated with older age (P<0.0001), higher systolic blood pressure (P<0.008), and use of antihypertensive medications (P<0.006), but not with 25(OH)D or PTH (both P>0.1). CONCLUSIONS:Carotid arterial stiffness is not associated with low 25(OH)D concentrations. Cross-sectional associations between arterial stiffness and high PTH were attenuated by systolic blood pressure. After nearly a decade of follow-up, neither baseline PTH nor 25(OH)D concentrations were associated with progression of carotid arterial stiffness.

SUBMITTER: Gepner AD

PROVIDER: S-EPMC4008121 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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25-hydroxyvitamin D and parathyroid hormone levels do not predict changes in carotid arterial stiffness: the Multi-Ethnic Study of Atherosclerosis.

Gepner Adam D AD Colangelo Laura A LA Blondon Marc M Korcarz Claudia E CE de Boer Ian H IH Kestenbaum Bryan B Siscovick David S DS Kaufman Joel D JD Liu Kiang K Stein James H JH

Arteriosclerosis, thrombosis, and vascular biology 20140403 5

<h4>Objective</h4>To evaluate the impact of vitamin D and parathyroid hormone (PTH) on longitudinal changes in arterial stiffness.<h4>Approach and results</h4>Distensibility coefficient and Young's elastic modulus of the right common carotid artery were evaluated at baseline and after a mean (SD) of 9.4 (0.5) years in 2580 Multi-Ethnic Study of Atherosclerosis (MESA) participants. Cross-sectional and longitudinal associations were evaluated using multivariable linear regression and analysis of c ...[more]

PMID: 24700125

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Project description:Increases in 25-hydroxyvitamin D concentrations are shown to improve strength in adults; however, data in pediatric populations are scant and equivocal. In this ancillary study of a larger-scale, multi-sited, double-blind, randomized, placebo-controlled vitamin D intervention in US children and adolescents, we examined the associations between changes in vitamin D metabolites and changes in muscle mass, strength, and composition after 12 weeks of vitamin D3 supplementation. Healthy male and female, black and white children and adolescents between the ages of 9 and 13 years from two US states (Georgia 34°N and Indiana 40°N) were enrolled in the study and randomly assigned to receive an oral vitamin D3 dose of 0, 400, 1000, 2000, or 4000 IU/d for 12 weeks between the winter months of 2009 to 2011 (N = 324). Analyses of covariance, partial correlations, and regression analyses of baseline and 12-week changes (post-baseline) in vitamin D metabolites (serum 25(OH)D, 1,25(OH)2 D, intact parathyroid hormone [iPTH]), and outcomes of muscle mass, strength, and composition (total body fat-free soft tissue [FFST], handgrip strength, forearm and calf muscle cross-sectional area [MCSA], muscle density, and intermuscular adipose tissue [IMAT]) were assessed. Serum 25(OH)D and 1,25(OH)2 D, but not iPTH, increased over time, as did fat mass, FFST, forearm and calf MCSA, forearm IMAT, and handgrip strength (p < 0.05). Vitamin D metabolites were not associated with muscle strength at baseline nor after the 12-week intervention. Changes in serum 25(OH)D correlated with decreases in forearm IMAT, whereas changes in serum iPTH predicted increases in forearm and calf MCSA and IMAT (p < 0.05). Overall, increases in 25(OH)D did not influence muscle mass or strength in vitamin D-sufficient children and adolescents; however, the role of iPTH on muscle composition in this population is unknown and warrants further investigation. © 2018 American Society for Bone and Mineral Research.

Dataset Information

25-hydroxyvitamin D and parathyroid hormone levels do not predict changes in carotid arterial stiffness: the Multi-Ethnic Study of Atherosclerosis.

Publications

25-hydroxyvitamin D and parathyroid hormone levels do not predict changes in carotid arterial stiffness: the Multi-Ethnic Study of Atherosclerosis.

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