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Meta-analyses between 18 candidate genetic markers and overweight/obesity.


ABSTRACT: AIMS: The goal of our study is to investigate the associations between 18 candidate genetic markers and overweight/obesity. METHODS: A total of 72 eligible articles were retrieved from literature databases including PubMed, Embase, SpingerLink, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang. Meta-analyses of 18 genetic markers among 56,738 controls and 48,148 overweight/obese persons were done by Review Manager 5.0. RESULTS: Our results showed that SH2B1 rs7498665 polymorphism was significantly associated with the risk of overweight/obesity (overall odds ratio (OR)?=?1.21, 95% confidence interval (CI)?=?1.09-1.34, P?=?0.0004). Increased risk of overweight/obesity was also observed in FAIM2 rs7138803 polymorphism (overall OR?=?1.11, 95% CI?=?1.01-1.22, P?=?0.04). CONCLUSION: Our meta-analyses have shown the important role of 2 polymorphisms (SH2B1 rs7498665 and FAIM2 rs7138803) in the development of overweight/obesity. This study highlighted the importance of above two candidate genes (SH2B1 and FAIM2) in the risk of overweight/obesity. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2785487401176182.

SUBMITTER: Tang L 

PROVIDER: S-EPMC4008255 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Meta-analyses between 18 candidate genetic markers and overweight/obesity.

Tang Linlin L   Ye Huadan H   Hong Qingxiao Q   Chen Fei F   Wang Qinwen Q   Xu Leiting L   Bu Shizhong S   Liu Qiong Q   Ye Meng M   Wang Dao Wen DW   Mai Yifeng Y   Duan Shiwei S  

Diagnostic pathology 20140312


<h4>Aims</h4>The goal of our study is to investigate the associations between 18 candidate genetic markers and overweight/obesity.<h4>Methods</h4>A total of 72 eligible articles were retrieved from literature databases including PubMed, Embase, SpingerLink, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang. Meta-analyses of 18 genetic markers among 56,738 controls and 48,148 overweight/obese persons were done by Review Manager 5.0.<h4>Results</h4>Our results showed th  ...[more]

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