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New molecular medicine-based scar management strategies.

ABSTRACT: Keloids and hypertrophic scars are prevalent disabling conditions with still suboptimal treatments. Basic science and molecular-based medicine research have contributed to unravel new bench-to-bedside scar therapies and to dissect the complex signalling pathways involved. Peptides such as the transforming growth factor beta (TGF-?) superfamily, with Smads, Ski, SnoN, Fussels, endoglin, DS-Sily, Cav-1p, AZX100, thymosin-?4 and other related molecules may emerge as targets to prevent and treat keloids and hypertrophic scars. The aim of this review is to describe the basic complexity of these new molecular scar management strategies and point out new fibrosis research lines.

SUBMITTER: Arno AI

PROVIDER: S-EPMC4008699 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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New molecular medicine-based scar management strategies.

Arno Anna I AI Gauglitz Gerd G GG Barret Juan P JP Jeschke Marc G MG

Burns : journal of the International Society for Burn Injuries 20140115 4

Keloids and hypertrophic scars are prevalent disabling conditions with still suboptimal treatments. Basic science and molecular-based medicine research have contributed to unravel new bench-to-bedside scar therapies and to dissect the complex signalling pathways involved. Peptides such as the transforming growth factor beta (TGF-β) superfamily, with Smads, Ski, SnoN, Fussels, endoglin, DS-Sily, Cav-1p, AZX100, thymosin-β4 and other related molecules may emerge as targets to prevent and treat kel ...[more]

PMID: 24438742

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