Ontology highlight
ABSTRACT:
SUBMITTER: Cox AG
PROVIDER: S-EPMC4008725 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Cox Andrew G AG Saunders Diane C DC Kelsey Peter B PB Conway Allie A AA Tesmenitsky Yevgenia Y Marchini Julio F JF Brown Kristin K KK Stamler Jonathan S JS Colagiovanni Dorothy B DB Rosenthal Gary J GJ Croce Kevin J KJ North Trista E TE Goessling Wolfram W
Cell reports 20140102 1
Toxic liver injury is a leading cause of liver failure and death because of the organ's inability to regenerate amidst massive cell death, and few therapeutic options exist. The mechanisms coordinating damage protection and repair are poorly understood. Here, we show that S-nitrosothiols regulate liver growth during development and after injury in vivo; in zebrafish, nitric-oxide (NO) enhanced liver formation independently of cGMP-mediated vasoactive effects. After acetaminophen (APAP) exposure, ...[more]