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Cytomegalovirus drives V?2neg ?? T cell inflation in many healthy virus carriers with increasing age.

ABSTRACT: Cytomegalovirus (CMV) usually causes lifelong asymptomatic infection, but over time can distort immune profiles. Recent reports describe selective expansion of V?2(neg) ?? T cells in healthy and immunocompromised CMV carriers. Having shown previously that virus-specific CD8(+) and CD4(+) T cell responses are increased significantly in elderly CMV carriers, probably driven by chronic stimulation, we hypothesized that V?2(neg) ?? T cells may also be expanded with age. Our results show that V?2(neg) ?? T cells are increased significantly in CMV-seropositive healthy individuals compared to CMV-seronegative controls in all age groups. The differences were most significant in older age groups (P?

SUBMITTER: Alejenef A

PROVIDER: S-EPMC4008987 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Cytomegalovirus drives Vδ2neg γδ T cell inflation in many healthy virus carriers with increasing age.

Alejenef A A Pachnio A A Halawi M M Christmas S E SE Christmas S E SE Moss P A H PA Khan N N

Clinical and experimental immunology 20140601 3

Cytomegalovirus (CMV) usually causes lifelong asymptomatic infection, but over time can distort immune profiles. Recent reports describe selective expansion of Vδ2(neg) γδ T cells in healthy and immunocompromised CMV carriers. Having shown previously that virus-specific CD8(+) and CD4(+) T cell responses are increased significantly in elderly CMV carriers, probably driven by chronic stimulation, we hypothesized that Vδ2(neg) γδ T cells may also be expanded with age. Our results show that Vδ2(neg ...[more]

PMID: 24547915

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