Leptin level and oxidative stress contribute to obesity-induced low testosterone in murine testicular tissue.
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ABSTRACT:
SUBMITTER: Zhao J
PROVIDER: S-EPMC4009340 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Leptin level and oxidative stress contribute to obesity-induced low testosterone in murine testicular tissue.
Zhao Jian J Zhai Lingling L Liu Zheng Z Wu Shuang S Xu Liping L
Oxidative medicine and cellular longevity 20140414
<h4>Objective</h4>This study evaluated the effects of obesity on the function of reproductive organs in male mice and the possible mechanism of male secondary hypogonadism (SH) in obesity.<h4>Methods</h4>Ninety-six mice were randomly assigned to three groups: the control group, diet-induced obesity group, and diet-induced obesity resistant group for 8 weeks and 19 weeks. The effects of short- and long-term high-fat diet on the reproductive organs were determined by measuring sperm count and moti ...[more]
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