Ontology highlight
ABSTRACT:
SUBMITTER: Kim S
PROVIDER: S-EPMC4009343 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Cell stem cell 20140401 4
In mice, clonal tracking of hematopoietic stem cells (HSCs) has revealed variations in repopulation characteristics. However, it is unclear whether similar properties apply in primates. Here, we examined this issue through tracking of thousands of hematopoietic stem and progenitor cells (HSPCs) in rhesus macaques for up to 12 years. Approximately half of the clones analyzed contributed to long-term repopulation (over 3-10 years), arising in sequential groups and likely representing self-renewing ...[more]